Levodopa increases memory encoding and dopamine release in the striatum in the elderly.

Author(s): Floel A, Garraux G, Xu B, Breitenstein C, Knecht S, Herscovitch P, Cohen LG

Affiliation(s): Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, USA. floeel@uni-muenster.de

Publication date & source: 2008-02, Neurobiol Aging., 29(2):267-79. Epub 2006 Nov 13.

Publication type: Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Normal aging is associated with a decrease in dopaminergic function and a reduced ability to form new motor memories with training. This study examined the link between both phenomena. We hypothesized that levodopa would (a) ameliorate aging-dependent deficits in motor memory formation, and (b) increase dopamine availability at the dopamine type 2-like (D2) receptor during training in task-relevant brain structures. The effects of training plus levodopa (100mg, plus 25mg carbidopa) on motor memory formation and striatal dopamine availability were measured with [(11)C]raclopride (RAC) positron emission tomography (PET). We found that levodopa did not alter RAC-binding potential at rest but it enhanced training effects on motor memory formation as well as dopamine release in the dorsal caudate nucleus. Motor memory formation during training correlated with the increase of dopamine release in the caudate nucleus. These results demonstrate that levodopa may ameliorate dopamine deficiencies in the elderly by replenishing dopaminergic presynaptic stores, actively engaged in phasic dopamine release during motor training.