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Trimipramine: acute and lasting effects on sleep in healthy and major depressive subjects.

Author(s): Feuillade P, Pringuey D, Belugou JL, Robert P, Darcourt G

Affiliation(s): Clinique de Psychiatrie et de Psychologie Medicale, Hopital Pasteur, Nice, France.

Publication date & source: 1992-03, J Affect Disord., 24(3):135-45.

Publication type: Clinical Trial

The acute effects of trimipramine on sleep EEG patterns were investigated in six depressed inpatients and six healthy volunteers. The effects of long-term administration were then assessed in depressed patients after 4 weeks of treatment. Sedative effects of the drug were more pronounced in healthy subjects while sleep parameters of depressed patients seemed less sensitive to the drug. Chronic effects tended to correct most of the sleep disturbances seen in depressed subjects with respect to the natural organization of sleep. The major sleep effect of trimipramine concerned REM latency which was lengthened in both groups, independently of the treatment protocol.

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