Nepafenac-associated bilateral corneal melt after photorefractive keratectomy.
Author(s): Feiz V, Oberg TJ, Kurz CJ, Mamalis N, Moshirfar M
Affiliation(s): Department of Ophthalmology and Vision Science, University of California-Davis, Davis, CA, USA.
Publication date & source: 2009-09, Cornea., 28(8):948-50.
Publication type: Case Reports; Research Support, Non-U.S. Gov't
PURPOSE: We are reporting a case of bilateral corneal melt after photorefractive keratectomy requiring bilateral corneal transplantations. RESULTS: A 35-year-old man underwent uncomplicated photorefractive keratectomy and was treated postoperatively with topical nepafenac, one drop in both eyes every 2 hours. Three days into this course of treatment, the patient developed bilateral irritation and the dose was decreased to one drop every 4 hours. The next day, he developed stromal melting in both eyes. Although nepafenac was discontinued at this point, the ulcerative keratolysis progressed in both eyes requiring penetrating keratoplasty. CONCLUSIONS: We report a case of sterile ulceration after photorefractive keratectomy surgery, which we believe was caused by frequent postoperative dosing of nepafenac.
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