DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Functional barriers: properties and evaluation.

Author(s): Feigenbaum A, Dole P, Aucejo S, Dainelli D, De la Cruz Garcia C, Hankemeier T, N'Gono Y, Papaspyrides CD, Paseiro P, Pastorelli S, Pavlidou S, Pennarun PY, Saillard P, Vidal L, Vitrac O, Voulzatis Y

Affiliation(s): INRA EMOA, Campus Moulin de la Housse, F-51687 Reims, France. alexandre.feigenbaum@reims.inra.fr

Publication date & source: 2005-10, Food Addit Contam., 22(10):956-67.

Publication type: Research Support, Non-U.S. Gov't

Functional barriers are multilayer structures deemed to prevent migration of some chemicals released by food-contact materials into food. In the area of plastics packaging, different migration behaviours of mono- and multilayer structures are assessed in terms of lag time and of their influence of the solubility of the migrants in food simulants. Whereas barriers to oxygen or to aromas must prevent the diffusion of these compounds under conditions of use, a functional barrier must also be efficient under processing conditions, to prevent diffusion of substances when the polymer layers are in contact at high (processing) temperatures. Diffusion in melted polymers at high temperatures is much slower for glassy polymers, than in polymers that are rubbery at ambient temperature. To evaluate the behaviour of functional barriers under conditions of use, a set of reference diffusion coefficients in the 40-60 degrees C range were determined for 14 polymers. Conditions for accelerated migration tests are proposed based on worst-case activation energy in the 40-60 degrees C range. For simulation of migration, numerical models are available. The rules derived from the models can be used both by industry (to optimize a material in terms of migration) or by risk assessors. Differences in migration behaviour between mono- and multilayer materials are discussed.

Page last updated: 2007-02-13

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017