Activities of moxifloxacin alone and in combination with other antimicrobial agents against multidrug-resistant Mycobacterium tuberculosis infection in BALB/c mice.

Author(s): Fattorini L, Tan D, Iona E, Mattei M, Giannoni F, Brunori L, Recchia S, Orefici G

Affiliation(s): Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita STA, Rome, Italy.

Publication date & source: 2003-01, Antimicrob Agents Chemother., 47(1):360-2.

Publication type:

The activity of moxifloxacin was enhanced by the addition of ethionamide but not by that of cycloserine, thiacetazone, capreomycin, para-aminosalicylic acid, or linezolid in BALB/c mice infected with a strain of Mycobacterium tuberculosis resistant to isoniazid, rifampin, and six other drugs. These observations are important for the therapy of multidrug-resistant tuberculosis.