Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.

Author(s): Farshid AA, Tamaddonfard E, Yahyaee F

Affiliation(s): Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, P.O. Box 1177, Urmia University, Urmia 57153, Iran. amirabbasfarshid@gmail.com

Publication date & source: 2010-11, Indian J Exp Biol., 48(11):1136-42.

The intra-plantar injection of carrageenan elicited an inflammatory response characterized by increase of the paw thickness and infiltration of neutrophils in paw tissues. Histidine, n-acetylcysteine and diclofenac decreased paw thickness, and neutrophil infiltration in the paw tissues. The anti-inflammatory effect induced by co-administration of histidine and n-acetylcysteine with diclofenac, was more than that obtained from histidine and n-acetylcysteine administered alone. The results suggested that histidine, n-acetylcysteine and diclofenac produced anti-inflammatory activities by reducing paw edema and neutrophil infiltrationin induced by carrageenan. Inhibition of cyclooxygenase products such as prostaglandins may be involved in the anti-inflammatory effects induced by histidine and n-acetylcysteine.