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Therapeutic role of zonisamide in neuropsychiatric disorders.

Author(s): Farooq MU, Moore PW, Bhatt A, Aburashed R, Kassab MY

Affiliation(s): Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48823, USA. muhammad.farooq@ht.msu.edu

Publication date & source: 2008-09, Mini Rev Med Chem., 8(10):968-75.

Publication type: Review

Zonisamide (ZNS), a sulfonamide antiepileptic drug, is indicated as an adjunct therapy for partial seizure disorders with and without secondary generalization. ZNS has a favorable pharmacokinetic profile because of its rapid absorption and high bioavailability. Its activity is related to the blockade of voltage gated sodium and calcium channels, modulation of central dopaminergic, GABAergic, and serotonergic functions, as well as inhibition of carbonic anhydrase and monoamine oxidase B. ZNS has potential efficacy for an array of neuropsychiatric disorders including migraine and other headache syndromes, neuropathic pain, Parkinson's disease, essential tremor, stroke, obesity, anxiety, bipolar and binge-eating disorders.

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