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A randomized controlled trial comparing artemether and quinine in the treatment of cerebral malaria in Bangladesh.

Author(s): Faiz MA, Rahman E, Hossain MA, Rahman MR, Yunus EB, Samad R, Hossain MA

Affiliation(s): Department of Medicine, Chittagong Medical College, Chittagong-4000, Bangladesh.

Publication date & source: 2001-03, Indian J Malariol., 38(1-2):9-18.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

A randomized controlled trial on 51 patients receiving artemether and 54 patients receiving quinine was undertaken to compare the effectiveness of intramuscular artemether and parenteral quinine in the treatment of cerebral malaria in adults in Bangladesh. Case fatality, fever and parasite clearance times were not significantly different in the two treatment groups. Coma resolution time was significantly delayed in artemether recipients. Results of the study suggest that treatment with artemether is as effective as parenteral quinine in the treatment of cerebral malaria in adults.

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