Efficacy of a low-concentration chlorhexidine mouth rinse in non-compliant
periodontitis patients attending a supportive periodontal care programme: a
randomized clinical trial.
Author(s): Escribano M, Herrera D, Morante S, Teughels W, Quirynen M, Sanz M.
Affiliation(s): Section of Graduate Periodontology, Faculty of Odontology, Complutense
University, Madrid, Spain.
Publication date & source: 2010, J Clin Periodontol. , 37(3):266-75
OBJECTIVE: To assess the clinical and microbiological efficacy of a 0.05%
chlorhexidine and 0.05% cetyl-pyridinium chloride mouth rinse in supportive
periodontal care (SPC) in patients with inadequate plaque control.
MATERIAL AND METHODS: The study was a randomized, double-blinded,
placebo-controlled clinical trial in patients with moderate to severe chronic
periodontitis under SPC with an inadequate plaque control (Turesky index >1).
After supragingival prophylaxis and oral hygiene reinforcement, participants
rinsed twice a day for 3 months with the test or placebo solutions, in addition
to conventional hygiene. Primary clinical outcome variables included plaque and
gingival indices. As secondary outcomes, periodontal and microbiological
variables were studied. ancova and chi(2) tests were used to compare the
variables.
RESULTS: Forty-seven patients (22 placebo and 25 test group) participated. After
3 months, plaque levels increased in the placebo group, while diminished in the
test group (p<0.001). Similar effects were found for bleeding on probing. The
other clinical parameters did not show significant differences. Microbiological
variables demonstrated inter-group significant reductions in subgingival counts
of Fusobacterium nucleatum and Prevotella intermedia and a decrease of the total
bacterial counts in saliva.
CONCLUSIONS: The tested mouth rinse demonstrated efficacy in reducing plaque and
gingivitis, as well as in decreasing the microbial load in saliva and gingival
sulcus.
|