[Topical administration of oxybutynin hydrochloride in women with urge incontinence. Results of a prospective randomized double-blind study]
Author(s): Enzelsberger H, Kurz C, Helmer H, Mittermayer F
Affiliation(s): I. Univ.-Frauenklinik Wien.
Publication date & source: 1995-05, Geburtshilfe Frauenheilkd., 55(5):240-3.
Publication type: Clinical Trial; Randomized Controlled Trial
Detrusor instability is the second most common cause of femal urinary incontinence. Oxybutynin chloride anticholinergic action with direct muscle-relaxant properties. 39 women with persistent-urgeincontinence participated in a pilot study of intravesical oxybutynin application. Patients received either 20 mg oxybutynin or placebo as 40 ml sterile sodium chloride solution administered intravesically over a period of 10 days. Urodynamic assessment as well as micturition protocols were performed before and after treatment. The intravesical oxybutynin-application was significantly better than the placebo application concerning reduction of pollakisuria and nycturia. Oxybutynin also increased bladder capacity more than in the placebo-treated group (p < 0.01) and provided an improvement of bladder compliance (p < 0.05). No local or systemic side effects were observed which would have immediately terminated the oxybutynin treatment.
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