Cimetidine does not influence TIL in breast cancer.

Author(s): Dwerryhouse SJ, Soon Lee C, King J, Magarey C, Schwartz P, Morris DL

Affiliation(s): Department of Surgery, The University of New South Wales, The St. George Hospital, Sydney, Australia.

Publication date & source: 1999, Int J Surg Investig., 1(3):191-4.

Publication type: Clinical Trial; Randomized Controlled Trial

Cimetidine is known to have immunomodulatory effects and this study aimed to examine the effect of pre-operative cimetidine treatment on lymphocytic infiltration in n = 72 women with breast cancer randomised to 400 mg bd or placebo for five days presurgery. A combined index was devised by adding infiltrating lymphocyte percentage and lymphoid score. There were no significant differences in circumferential infiltrate and lymphoid follicles in cimetidine treated patients and control patients with breast cancer.