Delivery of HFA and CFC salbutamol from spacer devices used in infancy.

Author(s): Dubus JC, Rhem R, Dolovich M

Affiliation(s): Department of Pediatrics, CHU Timone-Enfants, 13385 Cedex 5, Marseille, France. hdubus@mail.ap-hm.fr

Publication date & source: 2001-07-03, Int J Pharm., 222(1):101-8.

Publication type:

The aim of the study was to compare the in vitro delivery of four salbutamol pressurized metered-dose inhalers (pMDIs) via the three spacer devices commonly used in European infants: Aerochamber-Infant, Babyhaler, and metallic NES-spacer. Emitted dose (ED) and fine particle dose (FPD, particles<5.8 microm) of each combination of spacer device and pMDI (chlorofluorocarbon-based Ventoline, Eolene, Spreor, and hydrofluoroalkane-based Airomir were measured respectively using unit dose sampling tubes (n=30 per combination) and an 8-stage cascade impactor (n=6 per group). The results were compared by analysis of variance and the Student-Newman-Keuls method. ED of Airomir was always greater than for Ventoline (P<0.05). FPD obtained with Ventoline was the lowest, with Eolene>Airomir=Spreor>Ventoline (P<0.05). Only Airomir produced a similar FPD with all three spacer devices. Chlorofluorocarbon-salbutamol pMDIs are not generics when used with spacer devices. The three spacer devices may be used interchangeably with Airomir.