Chemotherapy: The role of ifosfamide and etoposide in Ewing sarcoma.
Author(s): DuBois SG, Grier HE
Affiliation(s): University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Publication date & source: 2009-05, Nat Rev Clin Oncol., 6(5):251-3.
Publication type: Clinical Trial, Phase III; Comment; Randomized Controlled Trial
The EICESS-92 Trial compared the efficacy of cyclophosphamide and ifosfamide in patients with Ewing sarcoma. Subgroup analysis suggested that patients with large, localized tumors benefited from the addition of etoposide, whereas patients with metastases did not.
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