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Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group.

Author(s): Dills DG, Schneider J

Affiliation(s): Department of Medicine, University of Wisconsin, Madison, USA.

Publication date & source: 1996-09, Horm Metab Res., 28(9):426-9.

Publication type: Clinical Trial; Randomized Controlled Trial

We report on the results of a one-year, multicenter, randomized, double-blind, parallel-group titration study of the new sulfonylurea agent, glimepiride, versus use of non-micronized glyburide to treat 577 patients with non-insulin dependent diabetes mellitus (NIDDM). Similar decreases in both fasting plasma glucose and HbA1C were found using glimepiride and glyburide. There was a lower incidence of hypoglycemia with glimepiride than glyburide.

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