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Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation.

Author(s): Diestelhorst M, Schmidl B, Konen W, Mester U, Raj PS

Affiliation(s): Department of Ophthalmology, University of Koln, Germany.

Publication date & source: 1996, J Cataract Refract Surg., 22 Suppl 1:788-93.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To compare the anti-inflammatory effect of diclofenac sodium 0.1% ophthalmic solution, flurbiprofen 0.03% ophthalmic solution, and indomethacin 1.0%. SETTING: Department of Ophthalmology, University of Koln, and Bundesknappschaftskrankenhaus, Sulzbach, Germany. METHODS: One hundred seventeen patients enrolled in this prospective, randomized, double-masked, and parallel-group study had phacoemulsification and intraocular lens implantation and received one of the three solutions. Preoperatively at day 1 and postoperatively at day 4 or 5 and day 12, 13, or 14, they were examined by slitlamp, applanation tonometry, and laser flare meter. RESULTS: Anterior chamber flare reduction from baseline was significantly greater in the diclofenac group than in the flurbiprofen group (P = .022). Patients in the diclofenac group had significantly less burning and stinging than those in the flurbiprofen and indomethacin groups at postoperative days 4-5 and 12-14 (P = .001). CONCLUSION: Diclofenac sodium appeared to be more potent than flurbiprofen in controlling intraocular inflammation after cataract surgery and appeared to be locally tolerated better than flurbiprofen and indomethacin.

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