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Use of antithrombin III in critical patients.

Author(s): Diaz-Cremades JM, Lorenzo R, Sanchez M, Moreno MJ, Alsar MJ, Bosch JM, Fajardo L, Gonzalez D, Guerrero D

Affiliation(s): Department of Hematology, Hospital Insular, Las Palmas de Gran Canaria, Spain.

Publication date & source: 1994-11, Intensive Care Med., 20(8):577-80.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To evaluate the effect of the AT III concentrates upon the clinical evolution and hemostatic parameters. DESIGN: Prospective, open, randomized trial. PATIENTS AND PARTICIPANTS: Septic and multiple trauma patients admitted to our Intensive Care Unit. SETTING: Levels of AT III below 70% were used as criteria to choose 36 patients, 20 of whom received treatment with AT III and 16 did not. INTERVENTIONS: AT III concentrates were administered at an initial dose of 60 U/kg followed by 10 U/kg every six hours. RESULTS: The administration of AT III neither contributes to alterations in haemostasis, nor the clinical evolution (evaluated according to Apache II score). CONCLUSIONS: The results suggest that the administration of AT III concentrates to critical patients with acquired low levels, but without manifest DIC, may not be justified; although further studies on a larger population are required to establish definite conclusions.

Page last updated: 2006-01-31

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