DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Bovine lactoferrin for Helicobacter pylori eradication: an open, randomized, multicentre study.

Author(s): Di Mario F, Aragona G, Dal Bo N, Cavallaro L, Marcon V, Olivieri P, Benedetti E, Orzes N, Marin R, Tafner G, Chilovi F, De Bastiani R, Fedrizzi F, Franceschi M, Salvat MH, Monica F, Piazzi L, Valiante F, Vecchiati U, Cavestro GM, Comparato G, Iori V, Maino M, Leandro G, Pilotto A, Rugge M, Franze A, Gastrointestinal Study Unit (GISU)

Affiliation(s): Gastroenterology, University of Parma, Parma, Italy. francesco.dimario@unipr.it

Publication date & source: 2006-04-15, Aliment Pharmacol Ther., 23(8):1235-40.

Publication type: Multicenter Study; Randomized Controlled Trial

BACKGROUND: Cure rates for eradication of Helicobacter pylori appear to be decreasing, thus more effective therapies must be identified. AIM: To evaluate the efficacy of bovine lactoferrin in the treatment of H. pylori infection. METHODS: In a multicentered prospective study, 402 (mean age 52.4, range 19-84 years) H. pylori-positive patients were assigned to one of three regimens: group A - esomeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for 7 days; group B - lactoferrin 200 mg b.d. for 7 days followed by the same schedule of group A; group C - esomeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. plus lactoferrin 200 mg b.d. for 7 days. RESULTS: Of the 402 patients, 389 completed the study. Six patients were discontinued due to side effects, one patient in group B died and six patients were lost to follow up. The eradication rate (intention-to-treat analysis) was 77% in group A (105/136), 73% in group B (97/132) and 90% in group C (120/134) (chi(2)-test P < 0.01). The incidence of side effects was 9.5% in group A, 9% in group B and 8.2% in group C (chi(2)-test P = 0.1). CONCLUSION: This study demonstrates that bovine lactoferrin is an effective adjuvant to 7-day triple therapy for eradication of H. pylori infection.

Page last updated: 2006-11-04

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017