[Effect of single-dose dexmedetomidine on recovery profiles after sevoflurane
anesthesia with spontaneous respiration in pediatric patients undergoing cleft
lip and palate repair]. [Article in Chinese]
Author(s): Di M(1), Huang C(1), Chen F(1), Zeng R(1), Yu C(1), Shangguan W(1), Lian Q(1), Li
J(2).
Affiliation(s): Author information:
(1)Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical
University, Wenzhou 325027, China. (2)Department of Anesthesiology, Second
Affiliated Hospital, Wenzhou Medical University, Wenzhou 325027, China. Email:
lijun0068@163.com.
Publication date & source: 2014, Zhonghua Yi Xue Za Zhi. , 94(19):1466-9
OBJECTIVE: To explore the effect of single-dose dexmedetomidine on recovery
period after sevoflurane anesthesia with spontaneous respiration in pediatric
patients undergoing cleft lip and palate repair.
METHODS: A total of 60 American Society of Anesthesiologists (ASA) I-II pediatric
patients undergoing cleft lip and palate repair from October to December 2013
were randomly divided into groups D and C (n = 30 each) . Dexmedetomidine 0.5
µg/kg (group D) or an equal volume of normal saline (group C) was ad ministered
intravenously over a period of 10 min at 30 min before the end of surgery.
Anesthesia was induced and maintained with sevoflurane under spontaneous
ventilation. Heart rate, mean arterial pressure (MAP), hemoglobin oxygen
saturation (SpO2), respiratory rate, tidal volume (VT) and pressure of end-tidal
carbon dioxide (PETCO2) were recorded at the time before induction (T0), 30 min
before the end of surgery (T1) , 20 min before the end of surgery (T2), 15 min
before the end of surgery (T3), 10 min before the end of surgery (T4), the end of
surgery (T5), extubation (T6), 5 min after transferal into post-anesthesia care
unit (PACU) (T7) , 1 h after surgery (T8) , extubation time, length of PACU stay,
fentanyl consumption and adverse events were all recorded. The incidence and
severity of coughing and emergence agitation were assessed.
RESULTS: Compared to T0, MAP and heart rate at T1 to T5 all decreased in two
groups (P < 0.05). MAP and heart rate at T6 both increased in two groups and
group C was higher than group D (P < 0.05). No inter-group differences existed in
SpO2, respiratory rate, VT or PETCO2. The incidence of coughing and emergence
agitation (30% and 13.3%), fentanyl consumption of group D (0.8 ± 2.1 µg) were
all significantly lower than that of group C [(66.7% vs 56.7%) and (4.9 ± 6.50)
µg, P < 0.05]. Length of PACU stay in group D was shorter than that in group C
[(15 ± 6) vs (23 ± 19) min, P < 0.05]. No inter-group difference existed in
extubation time or adverse events.
CONCLUSION: A single intravenous dose of dexmedetomidine is effective in reducing
emergence agitation and coughing, shortening length of PACU stay and improving
the quality of recovery period after sevoflurane anesthesia in pediatric patients
undergoing cleft lip and palate repair.
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