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A placebo-controlled double-blind randomized study of venlafaxine in the treatment of depression in dementia.

Author(s): de Vasconcelos Cunha UG, Lopes Rocha F, Avila de Melo R, Alves Valle E, de Souza Neto JJ, Mendes Brega R, Magalhaes Scoralick F, Araujo Silva S, Martins de Oliveira F, da Costa Junior AL, Xavier Faria Alves V, Sakurai E

Affiliation(s): Geriatric Unit, Governador Israel Pinheiro Hospital, Minas Gerais, Brazil.

Publication date & source: 2007, Dement Geriatr Cogn Disord., 24(1):36-41. Epub 2007 May 10.

Background/Aims: To evaluate the efficacy and safety of venlafaxine in the treatment of major depression in dementia. Methods: Thirty-one outpatients who had dementia and major depression participated in this randomized, double-blind, placebo-controlled, 6-week, flexible dose clinical trial. The screening measures were Cornell Scale for depression in dementia, DSM-IV for depression and dementia and Mini-Mental State Examination. The outcome measures were response rate, Montgomery-Asberg Depression Rating scale and Clinical Global Impressions. Results: The percentage of patients defined as Montgomery-Asberg Depression Rating scale responders was approximately the same in the placebo and in the venlafaxine groups. Clinical Global Impressions showed no significant difference between the groups. The reasons for dropouts show borderline significance between the two groups. There was no statistically significant difference in the incidence of adverse events between the venlafaxine and placebo-treated groups. Conclusions: Our data do not support the hypothesis that venlafaxine improves mood in elderly demented patients. Copyright (c) 2007 S. Karger AG, Basel.

Page last updated: 2007-08-04

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