Effects of rivastigmine on motor and cognitive impairment in Huntington's disease.
Author(s): de Tommaso M, Specchio N, Sciruicchio V, Difruscolo O, Specchio LM
Affiliation(s): Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy. m.detommaso@neurol.uniba.it
Publication date & source: 2004-12, Mov Disord., 19(12):1516-8.
Publication type: Clinical Trial; Randomized Controlled Trial
To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration. 2004 Movement Disorder Society.
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