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Treatment of recurrent aphthous stomatitis with clofazimine.

Author(s): de Abreu MA, Hirata CH, Pimentel DR, Weckx LL

Affiliation(s): Postgraduate student, Stomatology Division; Chief, Dermatology Service, Paulista West University, Presidente Prudente, Department of Otorhinolaryngology and Head Neck Surgery, Federal University of Sao Paulo, Sao Paulo, Brazil.

Publication date & source: 2009-11, Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 108(5):714-21. Epub 2009 Aug 20.

OBJECTIVE: The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis. STUDY DESIGN: In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms. RESULTS: A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with </=6% in the other groups). A significantly greater percentage of treatment interruption occurred in the colchicine group because of gastrointestinal effects (23%-45%). Individuals in the clofazimine group who continued to suffer from aphthous stomatitis presented with better results for the evaluated variables. CONCLUSION: Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.

Page last updated: 2009-10-20

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