Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.

Author(s): Danzi S, Klein I, Portman MA

Affiliation(s): Division of Endocrinology, Department of Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, New York, USA.

Publication date & source: 2005-03-15, Am J Cardiol., 95(6):787-9.

Publication type: Clinical Trial; Randomized Controlled Trial

We tested the hypothesis that triiodothyronine (T3) supplementation alters gene transcription in the left ventricular myocardium of infants undergoing cardiopulmonary bypass for ventricular septal defect repair. To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass.