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Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne.

Author(s): Cunliffe WJ, Holland KT

Affiliation(s): Department of Dermatology, Leeds General Infirmary, Yorkshire, England.

Publication date & source: 1989, Acta Derm Venereol Suppl (Stockh)., 143:31-4.

Publication type: Clinical Trial; Controlled Clinical Trial

In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months. No changes in sebum excretion rate occurred, but a significant reduction, 15.9 to 10.5%, of free fatty acids of skin surface lipid was detected after 1 month. The follicular Micrococaceae density was significantly reduced after 1 month, and after 2 months there was a significant reduction in follicular Propionibacterium spp density. The final reductions were 2,500 and 44 fold, respectively.

Page last updated: 2006-01-31

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