Use of spironolactone in treatment of hirsutism.
Author(s): Cumming DC
Affiliation(s): Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Canada.
Publication date & source: 1990-05, Cleve Clin J Med., 57(3):285-7.
Spironolactone (Aldactone), 100 mg to 200 mg daily, has antiandrogenic effects that may enhance treatment of androgen-excess syndromes, particularly severe hirsutism. Combination therapy with an oral contraceptive or with dexamethasone appears to have a beneficial effect. Side effects are transient. The drug should be avoided during pregnancy and in women who have a family history of breast cancer, although there is no proven association between spironolactone and breast malignancy.
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