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Anticholinergic medication for the unstable bladder: prospective trials of imipramine/propantheline versus penthienate and oxybutynin versus penthienate.

Author(s): Clarke B

Affiliation(s): Department of Obstetrics and Gynecology, University of Queensland and Royal Women's Hospital, Australia.

Publication date & source: 1996, Int Urogynecol J Pelvic Floor Dysfunct., 7(4):191-5.

Publication type: Clinical Trial; Randomized Controlled Trial

A comparison was made of three drug regimens: imipramine (Tofranil)/propantheline, oxybutynin (Ditropan) and penthienate bromide (Monodral). Two comparative trials were performed in prospective studies, using a randomization and cross-over design. All the drugs were found to improve the urinary symptoms and urodynamic changes associated with the unstable bladder, but penthienate was shown to be more effective than imipramine/propantheline. Its effect on the unstable bladder was equivalent to that of oxybutynin. Side-effects were common and most common with oxybutynin. However, the inability of these drugs to prevent the uninhibited detrusor contractions of the unstable bladder consistently and objectively was demonstrated.

Page last updated: 2006-01-31

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