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A new mucoadhesive dosage form for the management of oral lichen planus: formulation study and clinical study.

Author(s): Cilurzo F, Gennari CG, Selmin F, Epstein JB, Gaeta GM, Colella G, Minghetti P

Affiliation(s): Department of Pharmaceutical Science "Pietro Pratesi", Universita degli Studi di Milano, Italy.

Publication date & source: 2010-11, Eur J Pharm Biopharm., 76(3):437-42. Epub 2010 Aug 11.

Publication type: Randomized Controlled Trial

The work aimed at studying a new mucoadhesive prolonged release tablet containing 24 mug clobetasol-17 propionate (CP) suitable for the management of oral lichen planus. Low swellable dosage forms were designed by combining a mucoadhesive polymer, i.e. poly(sodium methacrylate, methylmethacrylate), with hydroxypropylmethylcellulose and MgCl. This formulation was selected to modify the tablet erosion rate in order to obtain a release of CP over a 6-h period. A double-blind, controlled study was performed using three groups of patient (n=16) who received three applications-a-day over 4 weeks of the developed CP tablets (group CP-T), placebo tablets (group CP-P) or commercial CP ointment for cutaneous application (123 mug/application) extemporary mixed with Orabase (group CP-O). At the end of the study, pain and ulceration resolved in 13/16 and 11/16 patients of group CP-T and group CP-O, respectively. In the group CP-O, a transient acute hyperaemic candidosis (n=2) and taste alteration (n=4) were also observed. No changes in clinical signs of patients in the group CP-P were evident. The application of mucoadhesive tablet containing 24 mug CP 3 times a day appeared to be effective, avoiding the side effects of the generally used treatment. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Page last updated: 2011-12-09

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