Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus.

Author(s): Chuang P, Langone AJ

Affiliation(s): Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223 Medical Center North, Nashville, TN 37232, USA. pealechuang@hotmail.com

Publication date & source: 2007-03, Am J Transplant., 7(3):714-7. Epub 2007 Jan 22.

Publication type: Clinical Trial

Aphthous ulceration is a common side effect of sirolimus. These lesions of the oral mucous membranes are often painful and debilitating, leading to either dose reduction or discontinuation of sirolimus in a significant number of patients. We report that the direct application of clobetasol, a high potency topical steroid, led to prompt resolution of the aphthous ulcers that developed in our renal transplant patients on sirolimus-based immunosuppression.