Maintenance tocolysis with oral micronized progesterone for prevention of preterm
birth after arrested preterm labor.
Author(s): Choudhary M(1), Suneja A(2), Vaid NB(2), Guleria K(2), Faridi MM(3).
Affiliation(s): Author information:
(1)Department of Obstetrics and Gynaecology, University College of Medical
Sciences and Guru Tegh Bahadur Hospital, Delhi, India. Electronic address:
manjuchoudhary04lhmc@gmail.com. (2)Department of Obstetrics and Gynaecology,
University College of Medical Sciences and Guru Tegh Bahadur Hospital, Delhi,
India. (3)Department of Pediatrics, University College of Medical Sciences and
Guru Tegh Bahadur Hospital, Delhi, India.
Publication date & source: 2014, Int J Gynaecol Obstet. , 126(1):60-3
OBJECTIVE: To evaluate the efficacy of maintenance therapy with oral micronized
progesterone (OMP) for prolongation of pregnancy in cases of arrested preterm
labor.
METHODS: Ninety women at 24-34weeks of singleton pregnancy with intact membranes
and arrested preterm labor were randomly allocated to receive OMP (n=45) or
placebo (n=45) daily until 37weeks or delivery, whichever was earlier. Outcome
parameters were compared using Student t test, χ(2) test, Fisher exact test, and
log-rank χ(2) test.
RESULTS: OMP significantly prolonged the latency period (33.29±22.16 vs
23.07±15.42days; P=0.013). Log-rank analysis revealed a significant difference in
mean time to delivery between the 2 groups (P=0.014). There were significantly
fewer preterm births (33% vs 58%; P=0.034) and low birth weight neonates (37% vs
64%; P=0.017), and significantly higher mean birth weight (2.44±0.58 vs
2.14±0.47kg; P=0.009) in the OMP group. Perinatal outcomes and adverse effects
were similar in the 2 groups.
CONCLUSION: Maintenance tocolysis with OMP significantly prolonged pregnancy and
decreased the number of preterm births. Clinical Trial Registry of India:
CTRI/2011/10/002043.
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