Combined use of botulinum toxin type A and B for forehead rhytides: a randomized,
double-blind, split-face study.
Author(s): Choi JW(1), Youn CS, An HT, Yoo JY, Na JI, Park KC, Youn SW, Huh CH.
Affiliation(s): Author information:
(1)Department of Dermatology, Seoul National University Bundang Hospital, Seongnam,
Gyeonggi-do, Korea.
Publication date & source: 2013, J Dermatolog Treat. , 24(2):126-32
BACKGROUND: This is the first well-controlled study of the combined use of
botulinum toxin type A (BoNT-A) and botulinum toxin type B (BoNT-B) for
hyperkinetic lines in forehead.
OBJECTIVE: To evaluate the effectiveness and safety of a mixture of BoNT-A and
BoNT-B with that of equipotent BoNT-A alone for treating patients with forehead
rhytides.
MATERIALS AND METHODS: Fourteen patients with forehead wrinkles completed this
clinical study. On day 0, patients received a mixture of BoNT-A (5 U) and B (500
U) on one side of the forehead and BoNT-A (10 U) symmetrically on the other side.
Clinical evaluation was made at the beginning and at weeks 1, 2, 4, 8, 12, and
16. Therapeutic efficacy was evaluated using clinical improvement scale by
investigators and the subjective wrinkle assessment by patients.
RESULTS: According to investigator assessment, the differences between the
average improvement scores of the two differently treated sides were not
statistically significant at all follow-up visits. Moreover, the plateau of the
clinical benefit was achieved at week 4.
CONCLUSION: We observed the equivalent efficacy in the mixture of both toxins and
BoNT-A alone.
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