Tegaserod and other serotonergic agents: what is the evidence?

Author(s): Chey WD

Affiliation(s): University of Michigan Health System, Ann Arbor, Michigan, USA.

Publication date & source: 2003, Rev Gastroenterol Disord., 3 Suppl 2:S35-40.

Publication type: Review

Through effects on gastrointestinal motor and secretory function as well as visceral sensation, serotonin (5-HT) plays a key role in the pathogenesis of irritable bowel syndrome (IBS). In particular, 5-HT3 and 5-HT4 receptors appear to be very important in IBS. This article critically appraises the evidence supporting the use of the 5-HT3 receptor antagonist alosetron in the treatment of women with diarrhea-predominant IBS. The safety profile and restricted-use program for alosetron is also reviewed. This discussion is followed by a comprehensive review of the efficacy and safety data in support of tegaserod for women with constipation-predominant IBS.