[Effect of vitamin B12 mixed solution inhalation for acute radiation-induced mucosal injury]

Author(s): Chen XL, Shi YS

Affiliation(s): Center of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. xianglongchen@21cn.com

Publication date & source: 2006-04, Nan Fang Yi Ke Da Xue Xue Bao., 26(4):512-4.

Publication type: English Abstract; Randomized Controlled Trial

OBJECTIVE: To evaluate the therapeutic effect of inhalation of vitamin B12 mixed solution in treating acute radiation-induced mucosal injury. METHODS: Totally 122 patients with acute radiation-induced mucosal injury resulting from radiotherapy were divided into two equal groups and received vitamin B12 mixed solution inhalation and gentamycin sulfate mixed solution inhalation, respectively. RESULTS: The patients receiving inhalation of vitamin B12 mixed solution showed favorable response to the treatment and the mucosal injury was alleviated as manifested by relieved pains, improved appetite and lessened body weight loss, which allowed uninterrupted administration of radiotherapy. In patients treated with inhalation of gentamycin sulfate mixed solution, by contrast, the mucosal injury was serious and in 8 patients radiotherapy had to be suspended for acute radiation-induced mucosal injury. CONCLUSION: Vitamin B12 mixed solution inhalation can be an effective treatment for acute radiation-induced mucosal injury.