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Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.

Author(s): Chapeland-Leclerc F, Hennequin C, Papon N, Noel T, Girard A, Socie G, Ribaud P, Lacroix C

Affiliation(s): EA 209-Eucaryotes Pathogenes: Transports Membranaires et Chimioresistance, Universite Paris Descartes, Paris, France.

Publication date & source: 2010-03, Antimicrob Agents Chemother., 54(3):1360-2. Epub 2009 Dec 28.

Publication type: Case Reports

We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.

Page last updated: 2010-10-05

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