Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient.
Author(s): Chapeland-Leclerc F, Hennequin C, Papon N, Noel T, Girard A, Socie G, Ribaud P, Lacroix C
Affiliation(s): EA 209-Eucaryotes Pathogenes: Transports Membranaires et Chimioresistance, Universite Paris Descartes, Paris, France.
Publication date & source: 2010-03, Antimicrob Agents Chemother., 54(3):1360-2. Epub 2009 Dec 28.
Publication type: Case Reports
We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C. glabrata FUR1 (CgFUR1) and CgFKS2 and overexpression of CgCDR1 and CgCDR2 were observed in resistant isolates.
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