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Colistimethate sodium therapy for multidrug-resistant isolates in pediatric patients.

Author(s): Celebi S, Hacimustafaoglu M, Koksal N, Ozkan H, Cetinkaya M

Affiliation(s): Uludag University Medical Faculty, Department of Pediatrics, Division of Pediatric Infectious Diseases, Gorukle, Bursa, Turkey. solmaz@uludag.edu.tr

Publication date & source: 2010-06, Pediatr Int., 52(3):410-4. Epub 2009 Dec 2.

AIM: The aim of the present study was to assess the efficacy and safety of colistimethate sodium therapy in multidrug-resistant nosocomial infections caused by Pseudomonas aeruginosa or Acinetobacter baumannii in neonates and children. METHODS: Pediatric patients hospitalized at the Uludag University Hospital who had nosocomial infections caused by multidrug-resistant P. aeruginosa or A. baumannii, were enrolled in the study. Colistimethate sodium at a dosage of 50-75 x 10(3) U/kg per day was given i.v. divided into three doses. RESULTS: Fifteen patients received 17 courses of colistimethate sodium for the following infections: ventilator-associated pneumonia (n= 14), catheter-related sepsis (n= 1) and skin and soft-tissue infection (n= 2). The mean age of patients was 53.2 + 74.7 months (range, 8 days-15 years) and 60% were male. Mortality was 26.6%. CONCLUSION: Colistimethate sodium appears to be safe and effective for the treatment of severe infections caused by multidrug-resistant P. aeruginosa or A. baumannii in pediatric patients.

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