[Comparative effectiveness of 0.1% metilprednisolone aceponate and 0.05% betamethasone dipropionate among children with nonretractable prepuce]

Author(s): Ceballos-Gonzalez S, Torres-Cantero C, Trujillo-Hernandez B, Muniz J, Huerta M, Trujillo X, Vasquez C

Affiliation(s): Servicio de Urologia, Hospital General de Zona y Medicina Familiar No. 1, IMSS, Colima, Colima, Mexico.

Publication date & source: 2006-03, Gac Med Mex., 142(2):121-4.

Publication type: Randomized Controlled Trial

OBJECTIVE: To compare clinical improvement between treatment with metilprednisolone aceponate vs. betamethasone dipropionate among children with nonretractable prepuce. MATERIAL AND METHODS: Between August 2001 and November 2002, we carried out a double blind and controlled clinical trial in 34 children with a diagnosis of nonretracable prepuce. Children were randomly assigned to one of the following groups and topical treatment was administered: Group A; metilprednisolone aceponate 0. I 1% and Group B; betamethasone dipropionate 0.05%. RESULTS: Improvement was noted in 88.2% of our sample studied; (n= 15) children from group A and 76.4% (n= 13) childrenfrom group B; however, we did not observe a significant difference when comparing percentages between the two groups (chi2 = 0.2; p = 0.6). CONCLUSIONS: The percentage of clinical improvement was similar between the two groups of topical steroid treatment administered.