Rapid onset of bronchodilation with formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler as compared to formoterol alone in patients with COPD.
Author(s): Cazzola M, Pasqua F, Ferri L, Biscione G, Cardaci V, Matera MG
Affiliation(s): Unit of Respiratory Clinical Pharmacology, Department of Internal Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy. firstname.lastname@example.org
Publication date & source: 2011-02, Pulm Pharmacol Ther., 24(1):118-22. Epub 2010 Sep 8.
Publication type: Comparative Study; Randomized Controlled Trial
In the present study, we examined whether there is a difference in the onset of bronchodilatation between formoterol/beclomethasone 12/200 mug Modulite and formoterol/budesonide 9/320 mug Turbuhaler in patients with COPD. We enrolled 28 patients with stable COPD. Both formoterol/beclomethasone and formoterol/budesonide elicited a larger mean FEV-AUCmin than formoterol alone, whereas there was no significant difference between their FEV-AUCmin. Also the change in FEV 15 min after inhalation of formoterol/beclomethasone combination or formoterol/budesonide combination was greater than that induced by formoterol alone. This study confirms the rapid effect of the inhaled corticosteroid component when combined with formoterol and indicates that the onset of bronchodilation of formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler are similar and greater than formoterol alone in patients with COPD. Copyright (c) 2010 Elsevier Ltd. All rights reserved.