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Long-term treatment of acne with 20% azelaic acid cream.

Author(s): Cavicchini S, Caputo R

Affiliation(s): First Clinic of Dermatology, University of Milan, Italy.

Publication date & source: 1989, Acta Derm Venereol Suppl (Stockh)., 143:40-4.

Publication type: Clinical Trial; Multicenter Study

Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris. During the period of 1982-86 we carried out two studies with 20% AZA cream in patients with acne to determine its clinical indications and therapeutic schedules. The first, open study was of 100 unselected patients of either sex, while a second group of 30 patients formed a part of a larger (309 patients) multicentre single-blind comparison of topical AZA vs. 5% benzoylperoxide (BPO) gel for the treatment of papulopustular acne. The rates of improvement obtained indicate that topical AZA can be considered an effective therapy chiefly for papulo-pustular acne, with a very good local tolerance.

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