A Double-Blind, Prospective, Randomized Controlled Trial Comparing Highly Cross-Linked and Conventional Polyethylene in Primary Total Hip Arthroplasty.

Author(s): Calvert GT, Devane PA, Fielden J, Adams K, Horne JG

Affiliation(s): Division of Orthopedic Surgery, Department of Surgery, Wellington School of Medicine, Wellington, New Zealand.

Publication date & source: 2008-06-09, J Arthroplasty., [Epub ahead of print]

Publication type:

Highly cross-linked polyethylene was developed to reduce articular bearing wear in total hip arthroplasty. In vitro studies have shown reduced wear in comparison with conventional polyethylene. A double-blind, prospective, randomized trial was performed comparing highly cross-linked and conventional polyethylene in 119 patients. The primary outcome variables were linear, 3-dimensional, and volumetric wear as determined by analysis of digitized radiographs using validated wear measurement software. Linear, 3-dimensional, and volumetric wear rates were significantly less in the highly cross-linked polyethylene group between 6 months and 4 years postoperatively (P < .05). The data presented here show that highly cross-linked polyethylene reduces short-term polyethylene wear. The intermediate and long-term clinical results of highly cross-linked polyethylene remain unknown pending further follow-up.