Nefazadone-induced acute dystonic reaction.

Author(s): Burda A, Webster K, Leikin JB, Chan SB, Stokes KA

Affiliation(s): Illinois Poison Center, Chicago, USA.

Publication date & source: 1999-10, Vet Hum Toxicol., 41(5):321-2.

Publication type: Case Reports

A 53-y-o patient presented approximately 2 h after taking her first dose of nefazadone. Chief complaint was lip smacking with hand and arm gesturing. The patient also took 25 mg meclizine which she had used before with no adverse effects. Diphenhydramine followed by benztropine led to resolution of symptoms within 1 h. Patient subsequently used meclizine with no untoward reactions. Nefazadone should be added to the list of agents that cause acute dystonic reactions.