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Seven day metronidazole versus single dose tinidazole as therapy for nonspecific vaginitis.

Author(s): Buranawarodomkul P, Chandeying V, Sutthijumroon S

Affiliation(s): Department of Obstetrics & Gynaecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Publication date & source: 1990-05, J Med Assoc Thai., 73(5):283-7.

Publication type: Clinical Trial; Randomized Controlled Trial

A comparative study of the treatment of nonspecific vaginitis was carried out in 171 reproductive-aged women. The patients were randomly treated with either metronidazole or tinidazole (Ninety-three patients in Group I, received oral metronidazole 1 g daily for 7 days. Another 78 patients in Group II, received oral tinidazole 2 g single dose. The patients were advised to return for follow-up examinations 1-2 weeks after treatment in their nonmenstrual period. Of these, 50 patients in each group were subject to complete study. The cure rates were 92 per cent in Group I and 86 per cent in Group II. The difference was not significant statistically. The adverse drug reactions among the two groups were 22 and 8 per cent respectively. Tinidazole is another effective drug for the treatment of nonspecific vaginitis.

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