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Antimicrobial efficacy of prophylactic gatifloxacin 0.3% and moxifloxacin 0.5% in patients undergoing phacoemulsification surgery.

Author(s): Bucci FA Jr, Amico LM, Evans RE

Affiliation(s): Bucci Laser Vision Institute, Wilkes Barre, PA 18702, USA. buccivision@aol.com

Publication date & source: 2008-01, Eye Contact Lens., 34(1):39-42.

Publication type: Research Support, Non-U.S. Gov't

PURPOSE: To evaluate the ocular surface and aqueous antimicrobial effects of gatifloxacin and moxifloxacin administered in two dosing regimens to patients undergoing phacoemulsification. METHODS: Patients were divided between two treatment groups and randomized to receive gatifloxacin 0.3% or moxifloxacin 0.5% within each group. Group 1 patients received antibiotics four times per day for 2 days before surgery with one additional drop the morning of surgery (n=50, each drug). Group 2 patients were treated as in group 1, plus four drops (one drop every 10 minutes) during the hour before surgery (n=60, each drug). Conjunctival and eyelid swabs were taken before surgery, and aqueous humor cultures were obtained immediately after surgery. Pathogens were identified and colony-forming units (CFUs) were counted. RESULTS: No differences were observed between the antibiotics in mean CFUs in conjunctival cultures from group 1 (gatifloxacin, 59.9+/-165.6 CFUs; moxifloxacin, 57.0+/-214.7 CFUs; P=0.939) or group 2 (gatifloxacin, 76.7+/-327.7 CFUs; moxifloxacin, 92.0+/-486.1 CFUs; P=0.830). No differences were observed between antibiotics in mean CFUs in eyelid cultures from group 1 (gatifloxacin, 198.1+/-330.1 CFUs; moxifloxacin, 168.3+/-379.0; P=0.840) or group 2 (gatifloxacin, 556.8+/-1,029.3 CFUs; moxifloxacin, 596.5+/-1,013.5 CFUs; P=0.832). The overall rate of positive aqueous cultures in the 220 patients from groups 1 and 2 combined was less than 1% (i.e., no difference between antibiotics in either group). CONCLUSIONS: Preoperative topical ophthalmic gatifloxacin and moxifloxacin produced similar preoperative eyelid and conjunctival bacterial counts and identically low postsurgical aqueous contamination rates.

Page last updated: 2008-03-26

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