Lithium use and primary hyperparathyroidism.
Author(s): Broome JT, Solorzano CC
Affiliation(s): Division of Surgical Oncology and Endocrine Surgery, Department of Surgical Sciences, Vanderbilt University, Nashville, Tennessee 37232-6860, USA. james.broome@vanderbilt.edu
Publication date & source: 2011-03, Endocr Pract., 17 Suppl 1:31-5.
Publication type: Review
OBJECTIVE: To review suspected causes of lithium-induced hyperparathyroidism, disease presentation, underlying pathology, and current recommendations and trends in medical and surgical treatment. METHODS: Relevant literature was reviewed. RESULTS: Lithium carbonate therapy has continued to be a mainstay of treatment for bipolar disease and schizoaffective disorder since its introduction into clinical use. Several metabolic consequences are associated with its long-term use, including hypercalcemia and hyperparathyroidism. CONCLUSIONS: Until further data become available, the surgeon should remain vigilant for the presence of pathologically active glands that may manifest their function at different times during the disease course.
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