Influence of the ageing phenomenon on the low-frequency electrical impedance behavior of naphazoline hydrochloride solutions and paracetamol syrup.

Author(s): Brito PC, Mechetti M, Gotter CM, Merep DJ

Affiliation(s): Laboratorio de Dielectricos, Departamento de Fisica, Facultad de Ciencias Exactas y Tecnologia, Universidad Nacional de Tucuman, Tucuman, Argentina. pbrito@herrera.unt.edu.ar

Publication date & source: 2009-05, J Pharm Sci., 98(5):1845-51.

Publication type: Research Support, Non-U.S. Gov't

The influence of the ageing process on the low frequency behavior of some electrical parameters of naphazoline hydrochloride solutions at 0.5% and 1% in concentration and of 2% paracetamol syrup, is studied. The impedance measurements were performed, in the range between 200 Hz and 1 MHz, using an impedance analyzer and a cell for liquids with plane parallel electrodes whose separation can be changed by using a set of spacers, provided by the manufacturer, in order to get better control of the influence of electrodes polarization effect. The ageing state was artificially generated by dilution and/or heating separated procedures. The results show that this dielectric technique can be used as a good quality complementary control technique.