Low-Dose Doxycycline Plus Additional Therapies may Lower Systemic Inflammation in Postmenopausal Women with Periodontitis.

Author(s): Bretz WA

Affiliation(s): New York University, College of Dentistry, 345 E. 24(th) Street, Room 1005, New York, NY 10010, Phone-FAX 212-9989914.

Publication date & source: 2011-12, J Evid Based Dent Pract., 11(4):194-5.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial. Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ. J Am Dent Assoc 2011;142;262-73. REVIEWER: Walter A. Bretz, DDS, PhD PURPOSE/QUESTION: To determine whether long-term subantimicrobial-dose-doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitis SOURCE OF FUNDING: NIH/NIDCR grant R01DE012872. TYPE OF STUDY/DESIGN: Randomized controlled trial LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence STRENGTH OF RECOMMENDATION GRADE: Not applicable. Copyright (c) 2011 Elsevier Inc. All rights reserved.