A double-blind, multicenter clinical trial comparing efficacy of once-daily metronidazole 1 percent cream to vehicle in patients with rosacea.

Author(s): Breneman DL, Stewart D, Hevia O, Hino PD, Drake LA

Affiliation(s): Dermik Laboratories, Inc., Collegeville, Pennsylvania 19426-1200, USA.

Publication date & source: 1998-01, Cutis., 61(1):44-7.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The efficacy and safety of a new formulation of metronidazole 1 percent cream applied once daily was compared to vehicle cream in a double-blind, randomized, parallel group, ten-week clinical study. The results showed that metronidazole 1 percent cream was significantly better than vehicle in reducing the lesions of rosacea, improving erythema, and physician's global rosacea scores. The incidence of adverse events related to the skin was low.