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Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder.

Author(s): Bowden CL, Calabrese JR, Ketter TA, Sachs GS, White RL, Thompson TR

Affiliation(s): Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA. bowdenc@uthscsa.edu

Publication date & source: 2006-07, Am J Psychiatry., 163(7):1199-201.

Publication type: Randomized Controlled Trial

OBJECTIVE: This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies. METHOD: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese patients with bipolar disorder from two double-blind, placebo-controlled, 18-month studies. RESULTS: Mean changes in weight among obese patients (N=155) at week 52 were -4.2, +6.1, and -0.6 kg with lamotrigine, lithium, and placebo, respectively (lamotrigine versus lithium and lithium versus placebo). Among nonobese patients (N=399), mean changes in weight (kg) at week 52 were -0.5, +1.1, and +0.7 with lamotrigine, lithium, and placebo, respectively, with no significant differences among groups. CONCLUSIONS: Obese patients with bipolar I disorder lost weight while taking lamotrigine and gained weight while taking lithium.

Page last updated: 2006-11-04

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