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[Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination]

Author(s): Boutelant S, Francillon A, Siche JP, Cocco-Guyomarch L, Mallion JM

Affiliation(s): Service de Consultation d'Hypertension Arterielle, CHRU-BP, Grenoble, France.

Publication date & source: 1995-07, Therapie., 50(4):313-8.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in). A significant fall of systolic (SBF) and diastolic (DBP) blood pressure at rest was seen after a 4-week treatment period in the two active groups (-21.9/-10.3 mmHg with BZ 10, -19.5/-11.2 mmHg with BZ + HCTZ) and was greater in these two groups than in the placebo group (-7.5/-2.5 mmHg, p < 0.01). For each level of the exercise test on bicycle ergometer, SBP falls seen after 1 month were significant in the two active groups (from -15 to -23 mmHg depending on the level and treatment group). The evolution of the SBP/heart rate slope was significantly different among the two active groups in favour of the BZ 10 regimen. The exercise test proved to be a valuable tool to show any difference between two treatments with comparable efficacy on SBP/DBP at rest.

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