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Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age.

Author(s): Booy R, Richmond P, Nolan T, McVernon J, Marshall H, Nissen M, Reynolds G, Ziegler JB, Heron L, Lambert S, Caubet M, Mesaros N, Boutriau D

Affiliation(s): National Centre for Immunisation Research and Surveillance, The Children's Hospital at Westmead, Sydney, Australia. robertb2@chw.edu.au

Publication date & source: 2011-04, Pediatr Infect Dis J., 30(4):340-2.

Publication type: Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer >/= 8 or anti-PRP concentration >/= 0.15 mug/mL. After 12 months, rSBA titer >/= 8 persisted in 86.7% and 76.4%, and anti-PRP concentration >/= 0.15 mug/mL persisted in 98.8% and 100% of children, respectively.

Page last updated: 2011-12-09

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