Behavioural aggression in panic disorder after 8 weeks' treatment with alprazolam.

Author(s): Bond AJ, Curran HV, Bruce MS, O'Sullivan G, Shine P

Affiliation(s): Department of Psychiatry, Institute of Psychiatry, University of London, UK.

Publication date & source: 1995-12-13, J Affect Disord., 35(3):117-23.

Publication type: Clinical Trial; Randomized Controlled Trial

23 patients with a diagnosis of panic disorder with agoraphobia were randomly assigned to 8 weeks' treatment with alprazolam or placebo. They filled in self-ratings before and after treatment and competed on a competitive reaction time task, designed to measure behavioural aggression, after 8 weeks' treatment. Patients taking both alprazolam and placebo rated decreased anxiety after 8 weeks' treatment but those on alprazolam also tended to report less hostility. On the behavioural task, patients on alprazolam behaved more aggressively in response to provocation. This is the first study to confirm clinical reports of benzodiazepine-induced dyscontrol on an objective laboratory measure. It is important that it is followed up in a larger group of patients.