Aliskiren alone or in combination with hydrochlorothiazide in Hispanic/Latino
patients with systolic blood pressure 160 mm Hg to <180 mm Hg (Aliskiren Alone or
in Combination with Hydrochlorothiazide in Patients with Stage 2 Hypertension to
Provide Quick Intensive Control of Blood Pressure [ACQUIRE] substudy).
Author(s): Black HR, Aguirre P F, Wright M, Alessi T, Baschiera F.
Affiliation(s): Section of Cardiology, New York University Center for the Prevention of
Cardiovascular Disease, New York University School of Medicine, New York, NY
10016, USA. hrbmd63@gmail.com
Publication date & source: 2012, J Clin Hypertens (Greenwich). , 14(8):514-21
In a prespecified subgroup analysis of a 12-week multinational, randomized,
double-blind, parallel-group trial, self-identified Hispanic/Latino adult men and
women with systolic blood pressure 160 mm Hg to 179 mm Hg received combination
aliskiren/hydrochlorothiazide (HCT) 150/12.5 mg or aliskiren 150 mg
(force-titrated to 300/25 mg and 300 mg, respectively, at week 1). At week 12,
combination aliskiren/HCT provided greater reduction in mean sitting systolic
blood pressure from baseline, the primary efficacy variable, compared with
aliskiren monotherapy (-32.6 mm Hg vs -19.6 mm Hg; P<.0001). Differences in mean
sitting diastolic blood pressure reductions followed a similar pattern (-13.5 mm
Hg vs -7.1 mm Hg; P<.0001). Notable blood pressure reductions were evident at
week 1 in both treatment groups, with near-maximal effects reached by week 8.
Results were consistent regardless of country of residence. Both treatments were
well tolerated. Aliskiren alone or in combination with HCT is safe and effective
in Hispanic/Latino patients with stage 2 hypertension. Combination aliskiren/HCT
produced greater blood pressure reductions than aliskiren monotherapy.
|