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Luteal phase progesterone increases live birth rate after frozen embryo transfer.

Author(s): Bjuresten K, Landgren BM, Hovatta O, Stavreus-Evers A

Affiliation(s): Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Publication date & source: 2011-02, Fertil Steril., 95(2):534-7. Epub 2010 Jun 26.

Publication type: Randomized Controlled Trial

OBJECTIVE: To see if progesterone support has a beneficial effect on live birth rate after frozen embryo transfer in natural cycles. DESIGN: Prospective randomized controlled trial. SETTING: University-based hospital. SUBJECT(S): Four hundred thirty-five women undergoing embryo transfer in natural cycles. INTERVENTION(S): The women received either vaginal progesterone, 400 mg twice a day from the day of embryo transfer in natural cycles, or no progesterone support. MAIN OUTCOME MEASURE(S): Live birth rate, biochemical pregnancy rate, pregnancy rate, and spontaneous abortion rate. RESULT(S): Live birth rate were significantly greater in women receiving vaginal progesterone as luteal phase support after frozen-thawed embryo transfer in natural cycles compared with those who did not take progesterone. There were no differences in biochemical pregnancy rate, pregnancy rate, or spontaneous abortion rate. CONCLUSION(S): Progesterone supplementation improves live birth rate after embryo transfer in natural cycles. Copyright (c) 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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